The two outsiders in Group C, however, head into this Friday night clash in different moods.
They last met at the last-16 stage in the 2021 edition of this tournament, with The Gambia coming out on top in an upset.
Still, it would be a shock if they manage to repeat that feat this evening.
Here’s how to watch all the action as the AFCON rolls on.
Where to watch Guinea vs Gambia
TV channel: The game will be broadcast live in the UK on Sky Sports Premier League. Coverage starts at 7:55pm GMT ahead of an 8pm kick-off.
Live stream: Subscribers will also be able to watch on a live stream online via the Sky Go app.