US Open fans have been left shattered after American hopeful John Isner announced he had to retire from the tournament after his first round win.
Isner toppled Federico Delbonis in straight sets to open his tournament on a high note, but a fall during his 6-3, 6-1, 7-5 win over the Argentinian left him in some doubt to go on.
With a second round match against 28th seed Holger Rune awaiting him, Isner was instead forced to withdraw from the tournament after further treatment showed he had fractured his left wrist.
It's a bitterly disappointing blow for the 37-year-old veteran, who looked to be in good form heading into the US Open, making the quarter-final of the Cinccinatti Open prior to the last grand slam of the year.
The world No.48 took to Twitter to announce the sad news.
Norway's Rune will move on to the third round via walkover, with American fans in particular heartbroken for the popular veteran.
"In my match yesterday I sustained a fall and subsequently fractured my left wrist," Isner wrote on Twitter.
"Extremely unfortunate and needless to say am pulling out of the tournament. See y’all in 2023."
In my match yesterday I sustained a fall and subsequently fractured my left wrist. Extremely unfortunate and needless to say am pulling out of the tournament. See y’all in 2023.
— John Isner (@JohnIsner) August 31, 2022
Fans were devastated for the in-form American on social media.
— Holger Rune (@holgerrune2003) August 31, 2022
Omg so sorry what a tough break
— Howie Schwab (@howieschwab) September 1, 2022
John Isner has withdrawn from #USOpen due to a wrist injury.
Danish teenager Holger Rune, 28th seed, is through to 3rd round where he'll face either 7th seeded Briton Cameron Norrie or unseeded Portuguese Joao Sousa
— Nihit (@nihitsachdeva28) August 31, 2022
Ouch! It's a long way to fall for you. Heal well!
— Tim Hall (@TimHall60617) August 31, 2022
NOOOOOOOOOOOO Big John!!! Speedy recovery for John Isner. Was excited for a good match between Isner and Rune. Wanted to see Isner have a good US Open run.
— William Horton (@WilliamHort0n) September 1, 2022
Meanwhile, Andy Murray survived an early scare to beat American wildcard Emilio Nava 5-7 6-3 6-1 6-0, moving into the third round of a grand slam for only the second time in five years.
Nava, the world No.203 who had knocked out Australian John Millman in the first round, showed he belonged further up the ladder with his confident shot-making on Wednesday, winning the big points to take a gruelling first set in 84 minutes.
Ten years since he won his maiden grand slam at Flushing Meadows, Murray struggled with his first serve but, always happy to graft in slams, broke the inexperienced Nava twice in the second set to level the match after the American made several unforced errors.
That fuelled the former World No.1 as he suddenly found his range on serve, tearing through the third set as Nava failed to sustain his levels from the opener and began to fade, giving the resolute Scot the advantage.
Alex de Minaur through to US Open third round after grand slam revenge
Alex de Minaur has avenged his Wimbledon defeat against Cristian Garin with a ruthless display in their US Open second round match on Wednesday in New York.
The Aussie powered into the last 32 at Flushing Meadows for the fourth time in five visits, courtesy of a thumping 6-3 6-0 4-6 6-2 victory.
Apart from a third set lull in which the 23-year-old let his Chilean opponent back into the contest, it was a brutal statement from Australia's 18th seed.
De Minaur could have been excused for having revenge on the mind after he squandered a two-sets-to-love lead and a match point, to go down to Garin in the fourth round at Wimbledon earlier this year.
That soul-crushing defeat at the All England Club was among the most toughest of de Minaur's career and the Aussie admitted this week that he wanted atonement in New York.
De Minaur wasted no time going to work in what proved to be a merciless act of cold-blooded revenge.
Clearly shaken by Garin's spirited Wimbledon comeback, when the South American played lights out for the last two and a half sets, de Minaur was intent from the outset of the return bout to set the record straight.
From 3-3 in the opening set, de Minaur turned the screws to reel off nine straight games and take a stranglehold on the match.
De Minaur, though, had to quickly regroup after dropping four consecutive games to concede the third set.
But that only made his victory more satisfying as he exorcised the demons of Wimbledon with a steely fourth set.
Click here to sign up to our newsletter for all the latest and breaking stories from Australia and around the world.