Both teams have had almost two weeks off thanks to the winter break and renew an intriguing rivalry with a place in the fifth round up for grabs.
Despite dominating English football for the best part of a decade, City's bogey team appears to be Spurs as on every visit to the Tottenham Hotspur Stadium so far they have failed to win a single point or score a single goal.
Friday's game could be the turning point, though, with Spurs missing captain Heung-min Son due to Asian Cup duties and City unable to welcome Erling Haaland back after over a month out through injury.
Date, kick-off time and venue
Tottenham vs Man City is scheduled for an 8pm GMT kick-off tonight on Friday January 26, 2024.
The match will take place at the Tottenham Hotspur Stadium.
Where to watch Tottenham vs Man City
TV channel: In the UK, tonight's game will be televised live and free-to-air on ITV, with coverage beginning at 7:30pm.
Live stream: Subscribers can also catch the contest live online via the ITVX app and website.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog, with expert analysis from Dan Kilpatrick at the ground.
Tottenham vs Man City team news
Tottenham XI: Vicario; Porro, Romero, Van de Ven, Udogie; Bentancur, Hojbjerg, Kulusevski; Johnson, Richarlison, Johnson
Subs: Forster, Royal, Davies, Dragusin, Skipp, Maddison, Bryan, Santiago, Scarlett
Manchester City XI: Ortega Moreno, Walker, Dias, Ake, Gvardiol, Rodrigo, Kovacic, Bernardo, Foden, Bobb, Alvarez
Subs: Ederson, Stones, Grealish, Doku, De Bruyne, Gomez, Nunes, Susoho, Lewis
Tottenham vs Man City prediction
Spurs will take heart from such an impressive home record against Manchester City, but the absence of Son will make this test far harder even with the return of Maddison.
City head into the game in good shape despite the continued absence of Haaland, with De Bruyne and Stones in contention to start. Who knows what will happen under the Friday night lights, but you feel the holders have the edge.
Man City to win, 2-1.
Head to head (h2h) history and results
Tottenham wins: 66
Man City wins: 66
Tottenham vs Man City match odds
Tottenham to win: 10/3
Man City to win: 4/6
Odds via Betfair (subject to change).