Semesa Rokoduguni could miss England's 2018 Six Nations campaign after Bath confirmed the wing is set to undergo shoulder surgery.
Rokoduguni, a try-scoring replacement in two November internationals for Eddie Jones' side, was hurt in his club's Premiership defeat to Exeter Chiefs last weekend.
Ahead of Bath's European Champions Cup clash with Toulon, director of rugby Todd Blackadder said: "One player who is not available is Roko, who will be going in for surgery on a shoulder injury sustained against Exeter.
"It's obviously a big loss, but we have the likes of Matt Banahan and Aled Brew among others, who can really cause the Toulon defence problems on Saturday."
It remains to be seen how long Rokoduguni will be sidelined for, with England's Six Nations campaign beginning on February 4.
Leicester Tigers prop Ellis Genge was ruled out for "a couple of months" due to a shoulder injury earlier this week, while influential Saracens forward Maro Itoje is also a doubt for the Six Nations after fracturing his jaw.