With rotations set to be at a minimum, those trusted to start at Hampden Park will know just how valuable an opportunity they will be getting in this hotly-contested friendly.
Here, we look at a Three Lions trio in need of a good performance...
The Arsenal goalkeeper faces intense competition at club level from David Raya, so will not want to pass up the chance to cement his status as England’s No2.
The Manchester City midfielder has played just six minutes for his club this season and, as it stands, appears unlikely to be given a more prominent role for them.
He remains Southgate’s go-to understudy for Jordan Henderson, however, and will know that tonight could be a rare chance to remind country and club of his talents.
Rashford was unlucky not to play more at the World Cup and will want to take his chance to make himself as undroppable as Bukayo Saka on the other flank.