First-half headers from Fran Kirby and Mia Fishel before late efforts from Guro Reiten and Maren Mjelde secured a comfortable 4-0 victory in the French capital for the Blues.
Emma Hayes' side had already guaranteed themselves a quarter-final spot and she took the opportunity to shuffle her pack.
After an even opening, it was England international Kirby who broke the deadlock with the visitors' first clear opportunity.
Jelena Cankovic crossed to the back post where Kirby arrived unmarked to head home for her first Champions League goal of the campaign.
The hosts, making their group-stage debut - having knocked Arsenal out earlier in the tournament - responded well as Chelsea goalkeeper Zecira Musovic was forced into a smart save, courtesy of an acute Mathilde Bourdieu.
Paris, though, had not learnt their lesson from Kirby's opener and were caught out in startlingly-similar fashion later in the half as Cankovic this time crossed for Fishel to head home.
With the hosts needing victory to keep alive their hopes of reaching the last eight, Julie Dufour missed a sitter after the restart, leaning back and firing over the crossbar from close range.
A number of defensive mix-ups allowed Chelsea to wrap up the win as Reiten was the beneficiary, tapping home after miscommunication on the edge of the Paris box.
There was more questionable defending as Mjelde flicked home a corner with goalkeeper Chiamaka Nnadozie poorly positioned.
Chelsea were good value for their win and will be seeded for the quarter-final draw on February 6 - avoiding some of Europe's big-hitters.
Additional reporting from PA