The first drive of the nationally-televised 'Thursday Night Football' ended with a terrifying moment when Parham appeared to knock himself out.
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Parham appeared to fall unconscious upon impact with the ground in the end zone after reeling in what would have been a touchdown pass from Justin Herbert.
Parham had the ball in his hands, but then his helmet snapped back and made hard contact with the turf.
The 24-year-old's arms immediately jolted up toward his helmet before his body went motionless on the ground.
A controversial close-up of his face showed his eyes closed.
Parham remained motionless on the ground for several minutes, with broadcaster Fox going to a commercial break.
They then went to to another break as Chargers trainers attended to Parham, while his teammates looked on in distress.
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He was eventually wheeled into an ambulance while strapped down on a stretcher with his arms visibly shaking.
The Chargers later announced that Parham had been taken to a hospital for further evaluation.
Fans and commentators took to social media to send their well-wishes.
"Scary scene on that field right now," wrote Robert Griffin III.
"Players put their livelihood on the line every time they step in between those lines. Prayers up for Donald Parham."
Derrick Johnson wrote: "Sucks that sometimes we have to see someone seriously hurt on the field to put things into perspective.
"Praying for Donald Parham".
Prayers for Donald Parham and his family. This is so awful.
— Bolt Beat (@BB_Chargers) December 17, 2021
Thoughts and prayers for Donald Parham
Scary situation 🙏 pic.twitter.com/GMjD17NIvQ
— Pickswise (@Pickswise) December 17, 2021
Scary scene on that field right now.
Players put their livelihood on the line every time they step in between those lines. Prayers up for Donald Parham
— Robert Griffin III (@RGIII) December 17, 2021
Sucks that sometimes we have to see someone seriously hurt on the field to put things into perspective. Praying for Donald Parham. 🙏🏽
— Derrick Johnson (@superdj56) December 17, 2021
That's completely gut wrenching. Prayers up for Donald Parham.
— Kent Swanson (@kent_swanson) December 17, 2021
The 24-year-old is in his second season with the Chargers after joining the team in April 2020 following the collapse of the XFL.
Through nine games this season, he had 20 catches, 190 receiving yards and three touchdowns on 26 targets.
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