The centre-back will be out for at least two months, though United are confident he will return before the end of the season.
Luke Shaw was an option to shift into the centre of defence as Erik ten Hag considers how to replace Martinez, but Erik ten Hag has opted for Harry Maguire and Victor Lindelof.
There is also concern over Aaron Wan-Bissaka’s fitness, with the right-back suffering a setback in training on Thursday.
“Aaron Wan-Bissaka today was training but then he dropped out, so I don't know in this moment where he is and what is the diagnosis,” Ten Hag revealed in his pre-match press conference.
“Hopefully he is not too bad.”
Mason Mount and Tyrell Malacia are still not ready to return to the United squad, while Anthony Martial also remains on the sidelines.
There are no surprises in attack, with Rasmus Hojlund set to lead the line after scoring in four of his last five Premier League matches, and Marcus Rashford and Alejandro Garnacho also hitting form either side of him.
Starting Man Utd XI: Onana; Dalot, Maguire, Varane, Shaw; Casemiro, Mainoo; Garnacho, Fernandes, Rashford, Hojlund
Subs: Bayindir, Evans, Lindelof, Amad, Amrabat, Eriksen, Forson, McTominay, Antony
Time and date: 4:30pm GMT on Sunday February 11
Venue: Villa Park
TV channel and live stream: Sky Sports