This time, the two teams will do battle to win a place in the quarter-finals of the competition in what is surely the headline fixture of the fourth round.
Erik ten Hag saw his side well beaten by rivals Manchester City on Sunday as his difficult start to the season continued. Newcastle, meanwhile, appear to have lost some of their energy in recent weeks as injury problems start to mount.
Here’s everything you need to know about tonight's game.
Date, kick-off time and venue
Manchester United vs Newcastle is scheduled for an 8.15pm GMT kick-off time tonight, Wednesday November 1, 2023.
Old Trafford in Manchester will host the contest.
Where to watch Manchester United vs Newcastle
TV channel: The game will be broadcast live on Sky Sports Football. Coverage starts at 7.30pm GMT.
Live stream: Subscribers will be able to watch online on a live stream via the Sky Go app.
LIVE coverage: Follow all the action with Standard Sport’s dedicated match blog.
Manchester United vs Newcastle lineups and team news
Manchester United vs Newcastle prediction
Manchester United do not look nearly as strong as last season but do have more depth available now.
With Howe expected to rotate what is already an injury-stricken Newcastle squad, the under-fire Ten Hag must be confident of sealing what would be a crucial win both for him personally and his team.
Manchester United to win, 2-1.
Head to head (h2h) history and results
Man United wins: 91
Newcastle wins: 44
Manchester United vs Newcastle odds
Manchester United to qualify: 13/20
Newcastle to qualify: 6/5
Odds via Betfair (subject to change).