Neither of these sides has ever won a knockout game at AFCON, but both have put up some surprise results in Ivory Coast.
The Lions of Chinguetti pulled off their first-ever win at a Cup of Nations by downing Algeria to book their spot as a third-placed side after opening the competition with two defeats.
Cape Verde, meanwhile, stunned Ghana before downing Mozambique and earning a dramatic draw with Egypt to impressively top Group B.
The winner of this match will face either Morocco or South Africa in a mouthwatering quarter-final.
Date, kick-off time and venue
Cape Verde vs Mauritania is scheduled for a 5pm GMT kick-off on Monday, January 29, 2024.
The match will take place at Stade Felix Houphouet-Boigny in Abidjan.
Where to watch Cape Verde vs Mauritania
TV channel: In the UK, the game will be televised live on Sky Sports Football and Main Event, with coverage starting at 4.55pm.
Live stream: Subscribers can also catch the contest live online via the Sky Go app.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog.
Cape Verde vs Mauritania team news
Bubista allowed a handful of his star players to sit out the Blue Sharks' draw with Egypt, having already won the group in double-quick time.
Former Manchester United man Bebe, top-scorer Ryan Mendes plus defenders Diney and Dylan Tavares should be among those returning.
Mauritania will likely stick with much of the team which earned a backs-to-the-wall 1-0 win over Algeria last time out.
Cape Verde vs Mauritania prediction
It is not unfair to say that Mauritania, with two defeats from three, scraped into the knockouts and now face a team which veritably flew past multiple giants of African football to win their group.
Knockout football can throw up some surprises - but Cape Verde are big favourites to keep rolling here.
Cape Verde to win, 2-0.
Head to head (h2h) history and results
Many of these teams' meetings have come in smaller competitions such as the Amilcar Cabral Cup.
Cape Verde wins: 5
Mauritania wins: 3
Cape Verde vs Mauritania match odds
Cape Verde to qualify: 1/1
Mauritania to qualify: 7/2
Odds via Betfair (subject to change).