The World Series will be played entirely at the Texas Rangers' new ballpark in Arlington, Texas, as part of a bubble agreement between Major League Baseball and the players' association.
It is the first time the sport's championship will be played entirely at one site since 1944.
The Division Series, League Championship Series and World Series all will be part of a bubble designed to minimise exposure to the coronavirus, which limited the regular season to a 60-game schedule for each club and caused 45 postponements.
Off days were eliminated for the Division Series and League Championship Series, which will stress pitching depth among starting rotations and bullpens.
The two traditional off days were retained for the World Series.
First-round best-of-three matchups in a postseason expanded from 10 to 16 teams this year will be held entirely at the higher-seeded clubs.
The final eight teams will shift to bubble environments.
"The agreement attempts to balance players' experiences and concerns while making the accommodations necessary to best ensure a safe, healthy and successful conclusion to the 2020 season," union head Tony Clark said in a statement.
The World Series will be at Globe Life Field in Arlington, a retractable roof stadium with artificial turf that opened this year adjacent to the Rangers' old ballpark.
The American League Championship Series will be at San Diego's Petco Park, and the NLCS at Globe Life.
The AL Division Series will be at San Diego and Los Angeles' Dodger Stadium, and the NL Division Series at Globe Life and Houston's Minute Maid Park.
MLB has not made any determinations on whether spectators will be allowed but is hopeful some percentage of seats can be filled in Texas.
While the NFL plays the Super Bowl at a neutral site selected in advance, baseball has resisted the idea, which has been long advocated by prominent agent Scott Boras.
The World Series was last played at one site in 1944 at Sportsman's Park in St. Louis, where the Cardinals beat the Browns 4-2 at the field both teams shared.
New York's Polo Grounds hosted all the games in 1921 and 1922, the last two seasons it was the home of both the New York Giants and Yankees.
The Giants won both titles.