West Indies Test captain Jason Holder and limited-overs skipper Kieron Pollard are among a group of players who will miss the upcoming tour of Bangladesh because of "COVID-19 related concerns or personal fears".
The pair, plus Darren Bravo, Shamarh Brooks, Roston Chase, Sheldon Cottrell, Evin Lewis, Shai Hope, Shimron Hetmyer and Nicholas Pooran, have declined selection for three one-day internationals next month and two Tests in February.
Opener Kraigg Brathwaite will take charge of the Test side while middle-order batsman Jason Mohammed is set to lead the ODI team for a tour where Fabian Allen and Shane Dowrich are also unavailable due to personal reasons.
As has been the case since the start of the pandemic, Cricket West Indies policy allows players to opt out of overseas tours on safety grounds and that decision will not impact on their consideration for future selection.
Batting duo Kavem Hodge and Shayne Moseley and all-rounder Kyle Mayers are uncapped at Test level but have been included in the 15-man red-ball group.
Left-arm spinner Akeal Hosein and batsman Kjorn Ottley have been called up to the 15-strong ODI squad for the first time.
"Although a number of the senior players are missing in both formats, I expect our teams to be very competitive," Cricket West Indies lead selector Roger Harper said.
"I expect our players to play with purpose, with passion and with the desire to prove that they belong at this level."