The South Americans travel to Lille having sat out the opening weekend of the competition, although their build-up went fairly well with wins over Chile and Namibia.
Few are expecting Uruguay to threaten Les Bleus, however, with the much-changed hosts expected to rack up a bonus point and a serious scoreline at the Stade Pierre-Mauroy.
France beat New Zealand 27-13 to open their tournament last Friday in what many have described as a statement victory as they seek to lift the Webb Ellis Cup for the very first time on home soil this autumn.
And their passionate home fans will be waiting on a big victory this evening to back up that performance.
Where to watch France vs Uruguay
TV channel: In the UK, Thursday’s game will be broadcast live and free to air on ITV4, with coverage starting at 7:15pm BST ahead of an 8pm kick-off.
Live stream: Fans can also catch the action live online via the ITVX website and app.
Live blog: Follow the game as it happens with Standard Sport’s dedicated live match blog.