Patrick Peterson intercepted Josh Allen with 1:12 left in overtime to finally end a tight contest between two of the NFL's best teams as Minnesota rallied from a 17-point second-half deficit on the road to beat the Buffalo Bills 33-30.
The Vikings took advantage of three turnovers by Allen in the fourth quarter and overtime, pulling ahead late in regulation when he mishandled a snap and fumbled in the end zone.
Greg Joseph put the Vikings ahead for good with a 33-yard field goal with 3:42 left in overtime.
The game didn't end until Allen, facing second and 10 at Minnesota's 20, forced a pass over the middle intended for Gabe Davis, only to have Peterson intercept it a few yards into the end zone.
Kirk Cousins threw for 357 yards, and Justin Jefferson had a monster game with 10 catches for 193 yards, including an incredible one-handed grab to convert a fourth-and-18 for the NFC North-leading Vikings (8-1).
The Bills (6-3) dropped out of the AFC lead with their second straight loss.
Tom Brady stayed undefeated abroad by throwing two touchdown passes as Tampa Bay beat Seattle 21-16 in the first regular-season game played in Germany.
German fans packed Allianz Arena for the historic game and the Bucs delivered with a balanced offensive performance on three long scoring drives. Rachaad White ran for 105 yards on 22 carries.
Brady completed 22 of 29 passes for 258 yards to add Germany to his list of international wins after victories in London (twice) and Mexico City with the New England Patriots, despite Seattle fighting back from 21-3 down to make it 21-16 with four minutes left.
In Green Bay, Aaron Rodgers threw three touchdown passes to rookie Christian Watson and led a 55-yard drive in overtime to set up Mason Crosby's game-winning field goal as the Packers beat Dallas 31-28.
Green Bay (4-6) trailed 28-14 in the fourth quarter before Rodgers led two long drives that ended with scoring passes to Watson.
The Cowboys (6-3) blew a 14-point lead heading into the fourth quarter for the first time in club history. They entered Sunday with a 195-0 record in such games, including playoffs.
In other games, the Indianapolis Colts won 25-20 at Las Vegas, Miami won 37-17 at home to the Cleveland Browns, the Arizona Cardinals won 27-17 at the Los Angeles Rams, the New York Giants beat the visiting Houston Texans 24-16, Tennessee won 17-10 at home to Denver, Detroit won 31-30 at Chicago, Kansas City beat the visiting Jacksonville 27-17, San Francisco beat the visiting LA Chargers 22-16, and Pittsburgh won 20-10 at home to the New Orleans Saints.