Striker Christian Pulisic and goalkeeper Ethan Horvath have combined to lead the United States to a comeback 3-2 win over Mexico.
Pulisic converted a penalty kick in the 114th minute and backup No.1 Ethan Horvath stopped Andres Guardado's penalty kick in the 124th as the Americans overcame an early defensive blunder in the final of the first CONCACAF Nations League.
The match turned on three video reviews.
Gio Reyna and Weston McKennie scored as the 20th-ranked US twice overcame deficits against No. 11 Mexico, who led after just 63 seconds.
Pulisic, fresh from winning the Champions League with Chelsea on May 29, cut inside the penalty area and was pulled down by Carlos Salcedo.
Panamanian referee John Pitti did not initially signal a penalty but consulted a video review and then pointed to the spot.
Mexico coach Tata Martino appeared to receive a red card for putting a hand on an official during the review and Hirving Lozano was given a yellow card for arguing after the decision.
Pulisic sent the ball to the upper corner past the left arm of goalkeeper Guillermo Ochoa for his 16th international goal.
Pitti again did not make a call when Luis Romo's header went off the left arm of McKenzie, whose arm was perhaps only slightly outstretched.
Horvath, who replaced injured starter Zack Steffen in the 69th minute, waited to the last moment and dived right to bat away the penalty by Mexico's captain.
The US had to survive an extended 11 minutes of stoppage time following the second extra period.
In a testy match, Reyna scored the first US goal and had been subbed off when appeared to be hit on the face by an object thrown from the stands following Pulisic's goal.
The match had been halted for about three minutes during second-half stoppage time because of discriminatory chants at Empower Field.
Jesus Corona put Mexico ahead 63 seconds in after a sloppy giveaway by McKenzie, who made a poor pass in his own penalty area right into the path Corona, who dribbled in alone on Steffen and sent an angled shot over the goalkeeper's right shoulder for his ninth goal.
Mexico appeared to go up 2-0 in the 24th minute when Hector Herrera played a short corner kick to Lozano, who gave the ball back, and Herrera made a long cross that unmarked Hector Moreno headed in.
After a brief delay for the video review, the goal was disallowed for offside.
Reyna scored his third international goal when Pulisic's corner kick was headed by McKennie off the far post and bounded in front of the goal, where Reyna kicked it in from about four yards with his left foot.