The AFL has switched two games to Sydney but is pressing ahead with a top-of-the-table clash in Melbourne despite Victoria's COVID-19 outbreak.
Gold Coast's match against Hawthorn, scheduled for Darwin, will now be played at the SCG on Saturday night.
Richmond's home game against Adelaide at the MCG on Sunday will now be played at Giants Stadium in western Sydney.
The changes come as Victoria prepares to enter a seven-day lockdown from midnight amid a worsening coronavirus situation.
All other games will proceed as scheduled, just with no crowds at Victorian venues.
Melbourne's blockbuster against the Western Bulldogs (both teams sit 9-1) at Marvel Stadium on Friday night will go ahead despite a Demons player attending a COVID-exposed site.
AFL CEO Gillon McLachlan said all Melbourne players and staffers have been tested for COVID-19 and were isolating while awaiting results.
The Demons player at risk will undertake a mandatory 14-day isolation period.
The shifted games were unable to be held at their original venues because of travel restrictions imposed by various state governments.
The start time for Port Adelaide's fixture against Fremantle on Sunday at Adelaide Oval has also been pushed back 30 minutes.
"The changes this week have been necessary to best deal with the evolving situation in Victoria and we thank the Victorian state government for allowing us to proceed with matches minus crowds," McLachlan said.
"As quickly as the landscape changes in the wider community, we are buoyed by the fact that our league and our competition have successfully worked through similar situations before.
"The changes are in place for this round only and the AFL will continue to monitor the situation over the coming days before making any decisions on future rounds.
"It's disappointing for fans in Victoria to not be able to attend the footy this weekend."
McLachlan said hubs were "not yet" a consideration but that could change should the lockdown fail to contain the outbreak in Victoria.
"We've got nine games scheduled for this weekend and we're looking ahead to the next two or three rounds, but they will be determined by what happens in the coming week," he added.
Essendon are already in Perth for Saturday night's clash with West Coast at Optus Stadium and could remain there for the Dreamtime match against the Tigers in round 12, a fixture which normally attracts at least 80,000 people to the MCG.
Carlton made it out of Melbourne on Wednesday and are currently in Sydney gearing up to face the Swans.
"We are communicating with (Victorians teams on the road) as regularly as we can," McLachlan said.
"They're not intending on being away weeks, maybe two games."
On Wednesday, strict restrictions were imposed on all Victorian-based AFL clubs, with players and staffers recommended to only leave their homes for playing, training and essentials.
All second-tier VFL matches have been postponed this weekend, as has all local football across Victoria.
AFL ROUND 11 CHANGES:
Gold Coast v Hawthorn, SCG (originally at Darwin's TIO Stadium), Saturday 7.40pm
Richmond v Adelaide, Giants Stadium (originally at the MCG), Sunday 2.10pm