Bernard Tomic will face unseeded Argentine Leonardo Mayer in the first round of the Australian Open, while Lleyton Hewitt will come up against eighth seed Janko Tipsarevic.
The draw was relatively kind for Tomic, who has yet to taste defeat in 2013, but he could face 17-time grand slam champion Roger Federer in the third round.
Hewitt has also began the year in fine form but will have a tough time against Serbian Tipsarevic in what is shaping as the pick of the first-round clashes.
Australia's number one Marinko Matosevic opens up against Croatian 13th seed Marin Cilic, while Matthew Ebden will take on Russian 24th seed Mikhail Youzhny.
John Millman will fancy his chances of winning his first ever grand slam match against Tatsuma Ito, while there is guaranteed to be at least one Australian man in the second round with wildcards James Duckworth and Ben Mitchell drawn to play each other.
Reigning champion Novak Djokovic begins his title defence against Frenchman Paul-Henri Mathieu and appears to have a relatively straight forward path to the final with world number three Andy Murray in the other half.
The Serbian does have Tomas Berdych in his quarter with fourth seed David Ferrer and Tipsarevic are the other top eight players in his half.
Federer begins his quest for an 18th major title against Benoit Paire, while US Open champion Murray will play Dutchman Robin Haase.
Sixth seed Juan Martin del Potro, who is likely to meet Murray in the quarters, takes on a qualifier and Jo-Wilfried Tsonga plays fellow Frenchman Michael Llodra in what is shaping the harder side of the draw.
In the women's draw, Australian ninth seed Sam Stosur has a tricky first match against Kai-Chen Chang, who she lost to in Osaka last year, before a possible second-round rematch against her Sydney conqueror Jie Zheng.
Teenage sensation Ash Barty will play Slovakian 15th seed Dominika Cibulkova, while Jarmila Gajdosva is up against 20th seed Yanina Wickmayer and Casey Dellacqua opens up against American youngster Madison Keys.
Tournament favourites Victoria Azarenka and Serena Williams both have straightforward opening matches against Monica Niculescu and Edina Gallovits-Hall respectively, but have been drawn in the same half and will meet in the semis if they both progress that far.
Former grand slam champions Francesca Schiavone and eighth seed Petra Kvitova meet in a blockbuster first-round clash, while 10th seed Caroline Wozniacki has a tough opening clash against Sabine Lisicki.