Manchester United have fought back from 1-0 down to overpower West Ham 3-1 and reach the FA Cup quarter-finals, while EPL sides Tottenham and Southampton both fell to lower-league opposition.

Three days after they won the League Cup, United trailed to Said Benrahma's 54th-minute strike at Old Trafford but an own goal by West Ham's Nayef Aguerd and late strikes from Alejandro Garnacho and Fred sent the hosts into the last eight.

"The resilience from this team and the belief they're going to win it was magnificent," United manager Erik ten Hag said.

"You saw the belief, there was composure, there was never a moment of panic."

United will host fellow top-flight outfit Fulham in the next round.

League Two Grimsby provided the shock of the night, continuing their dream FA Cup run as two penalties from Gavan Holohan knocked out Southampton on their own ground.

"I am very disappointed with the performance and the result," Southampton's manager Ruben Selles said.

Known as the Mariners, Grimsby - sitting 16th in the fourth-tier - were backed by more than 4000 boisterous fans waving inflatable fish in honour of the east coast club's port-side roots.

They moved into the last eight for the first time in 84 years, where they will face Premier League high-flyers Brighton in a bid to improve their record run of defeating five teams from higher divisions in a single FA Cup campaign.

"They deserve to have maybe more celebrations than what they will get," Grimsby manager Paul Hurst said of his squad, who travel to promotion-chasing Carlisle on Saturday.

"They did enjoy it in the dressing room. Looking around at a few of their faces, they were in shock, probably very tired as well.

"I'm just pleased for them. It's a memory for them, for the owners, for the supporters - and we go down in history because of the way we've got to the quarter-finals."

Tottenham suffered a 1-0 loss at Championship side Sheffield United, Iliman Ndiaye scoring 11 minutes from time for the tier-two side to stun the visitors.

"There were 5000 of (our fans) here to watch our performance and we apologise because we missed a big opportunity," Tottenham's assistant head coach Cristian Stellini said.

"When the energy is not at the same level as your opponent sometimes you can lose."

Sheffield United's reward is an all-Championship last-eight tie against Blackburn.

Championship leaders Burnley beat Fleetwood Town 1-0 in the other tie to earn a visit to Manchester City in the last eight.

FA Cup quarter-final draw:

Manchester City v Burnley

Manchester United v Fulham

Brighton & Hove Albion v Grimsby Town

Sheffield United v Blackburn Rovers

Ties to be played between March 17-19.

- with PA