Dubbo will host a first-grade NRL match for the first time in 2021, with South Sydney set to take a home game to the regional NSW city for the next two years.
The Rabbitohs will confirm matches in the central western NSW city on Thursday as part of the NRL's return to the bush.
It will mark the first NRL match at Apex Park, with the venue having previously hosted City-Country and midweek competition games in the 1990s.
The town has produced several NRL players, including Les Davidson, Don Parish Dean Pay, Andrew Ryan and current Penrith players Isaah Yeo and Matt Burton.
Souths generally take three matches away from Sydney each year, with the Sunshine Coast and Central Coast their other two regular venues.
The NRL is desperate to take more games to regional venues, with eight originally slated into this year's schedule before COVID-19 stopped most from going ahead.