A season-high 23 points for Ben Simmons, along with 11 rebounds and nine assists, was not enough to prevent his Philadelphia 76ers slumping to a 118-114 defeat at the hands of the Trail Blazers.
Damian Lillard had 30 points and Carmelo Anthony added 24 off the bench, including 16 in the fourth quarter, to help Portland win for the fourth time in five games.
Joel Embiid led the 76ers with 35 points and nine rebounds in a loss that snapped a four-game winning streak for Philadelphia.
A back-and-forth game was locked at 114-each with 22.1 seconds left on the clock, before Portland pulled away at the death.
While it was a disappointing result for Simmons, he recorded his best scoring quarter of the season as a 13-point opening period set the tone for a standout performance.
In Boston, Semi Ojeleye had a career-high 24 points and six 3-pointers as the Celtics rolled to a 120-106 win victory over the Toronto Raptors.
Rookie Payton Pritchard added 20 points and had a career-high six 3s to help Boston snap a two-game skid.
The Celtics never trailed and led by 19, thanks in part to a season-high 20 3-pointers.
Kyle Lowry led the Raptors with 24 points and six assists, while Australia's Aron Baynes scored eight points.
Jimmy Butler had a triple-double with 27 points, 10 rebounds and 10 assists as Miami overcame a slow start to beat the slumping Rockets.
Miami won their fourth straight match, in the process handing Houston their fourth successive defeat.
Stephen Curry made 10 3-pointers and had 40 points, eight rebounds and five assists, as he led Golden State past undermanned Orlando.
The two-time MVP has made at least four 3-pointers in a career-best 13 straight games.
Domantas Sabonis had 26 points, eight rebounds and eight assists as Indiana beat Detroit to end a four-game losing streak.
Malcolm Brogdon added 18 points, and Jeremy Lamb had 17.
Josh Jackson led Detroit with 18 points, while rookie Isaiah Stewart added 17 in his first start at center.