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Barcelona have suffered a shock 1-0 home defeat to Rayo Vallecano that means Real Madrid can step up plans for their La Liga title party.
This was a third consecutive home loss for the Catalans, only the second time Barcelona have suffered such a fate in their history, with Alvaro Garcia's early strike the difference.
It means Real Madrid's lead at the top is 15 points with five games remaining, putting Los Blancos on the brink of being crowned champions.
That will be confirmed if Carlo Ancelotti's team avoid defeat to Espanyol next Saturday, while Xavi's Barcelona have slackened their grip on second place with this setback.
Vallecano, sitting 14th before their arrival at Camp Nou, took a seventh-minute lead when Garcia made a smart run into space to meet a chipped pass from Isi Palazon and fired sharply into the bottom right corner.
Jordi Alba curled a shot that flicked wide off the post as Barcelona chased an equaliser, then Gavi wanted a penalty when he slumped to the turf under a nothing challenge from Santiago Comesana.
Referee Isidro Diaz de Mera Escuderos was unimpressed and booked coach Xavi for taking his complaints too far.
A clever floated shot from Gavi hit the crossbar shortly before half-time, and although Ferran Torres lobbed the ball into the net from the rebound, he had been in an offside position.
Jordi Alba had a shot deflect over as Barcelona pushed early in the second half, but the home side were horribly flat, with Ferran Torres and Frenkie de Jong replaced by Memphis Depay and Nico Gonzalez as Xavi looked to inject some energy.
Depay had a close-range shot blocked by Nikola Maras, and the Dutch striker saw a stinging 20-yard strike punched over the bar by Stole Dimitrievski, but the equaliser would not come.
Barcelona will have home advantage against next Sunday when Real Mallorca visit Camp Nou while Vallecano host Real Sociedad.