Cormac Daly, who moved to Sydney last year for an office job, will become the first Irishman to start for the Queensland Reds since 1997.
Stephen Larkham says his high-flying Brumbies must not rest on their laurels despite a five-game winning streak that has them third on the Super Rugby ladder.
Izack Rodda and Kurtley Beale will bolster the Western Force's stocks, while the Reds have made mass changes as they aim to end a three-match losing streak.