Paris Saint-Germain were held to a 1-1 draw away to Saint-Etienne in coach Mauricio Pochettino's first game in charge of the champions, to lose further ground in the Ligue 1 title race.
Pochettino had a rude awakening as Romain Hamouma put Saint-Etienne ahead after 19 minutes, after PSG midfielder Idrissa Gueye lost the ball near the penalty area.
Moise Kean equalised three minutes later when he was teed up by midfielder Marco Verratti.
Kean then shot over the bar with 20 minutes left, just moments after Saint-Etienne striker Denis Bouanga headed an effort against the woodwork.
Memphis Depay's double and a Steven Fortes own goal gave Lyon a 3-2 win over Lens to open up a three-point lead at the top.
The leaders are now unbeaten in their past 15 games.
PSG are second spot, three points adrift of Lyon, after Lille were beaten 2-1 at home by Angers.
Lille were two-goals down after 11 minutes, with midfielder Romain Thomas grabbing both for Angers, before veteran Turkey striker Burak Yilmaz pulled one back in the 41st.
Veteran coach Raymond Domenech's first match in charge of Nantes ended in a 0-0 draw at home to fourth-place Rennes.
Fifth-placed Monaco romped to a 5-2 win at Lorient with Axel Disasi, Aleksandr Golovin, Kevin Volland, Sofiane Diop and Guillermo Maripan on target.
Marseille are eighth, but have two games in hand over the sides above them, after an impressive 3-1 victory over Montpellier.
Winger Nemanja Radonjic made the most of a rare start when he headed in Florian Thauvin's cross close to halftime before Montpellier replied through midfielder Florent Mollet.
But Marseille's substitutes made the difference as playmaker Dimitri Payet - surprisingly left on the bench to start the game - and Valere Germain netted in the last 10 minutes.
Elsewhere, Brest beat Nice 2-0 to be 10th while Ludovic Ajorque scored twice as Strasbourg thrashed bottom side Nimes 5-0.
Metz and Bordeaux failed to trouble the scorers while Reims and Dijon also played out a goalless draw.