It has taken the work of five artists, chosen by the Royal Academy, to bring the amazing art to the streets around the tourist hotspot.
Known as a “gallery without walls”, it is made up of the most art crossing ever to be exhibited in one location in the UK.
The artists behind the colourful transformation are Michael Armitage, Vanessa Jackson, Isaac Julien, Farshid Moussavi and Yinka Shonibare.
Their work will remain on display until August 31 as part of the Art of London summer season, with takeovers of the 780 sqm Piccadilly Lights also set to take place weekly.
For the first time, audiences will be able to take part in a special augmented reality 10-screen experience and audio sync via their mobile phones.
The installations site for the Piccadilly Art Takeover are also part of the Let’s Do London campaign, backed by £7m from the Mayor of London, Visit London, Transport for London and the tourism industry.