Just when their injury crisis appeared to be slowing down, Penrith have suffered another injury blow after skipper Peter Wallace was ruled out for two weeks with a shoulder injury.
The veteran hooker had been carrying the injury for a number of matches but aggravated the issue during last week's NRL win over Newcastle.
Youngster Sione Katoa has been named in the No.9 jumper for Thursday's round 11 clash against the Wests Tigers, with rookie rake Wayde Egan on the bench.
Veteran James Maloney will captain the Panthers in the absence of Wallace, who also missed a match earlier this year due to a neck problem.
"He's got a tendon problem in his shoulder," Griffin said of Wallace on Wednesday.
"It wasn't too bad but it flared up after the game. We had some scans on him on Saturday and the medical staff have said a couple of weeks to settle it down."
While halfback Nathan Cleary makes his anticipated return from a seven-week layoff with a knee injury, Wallace's absence robs Griffin of fielding his strongest spine.
He's already had to deal with losing first-choice fullback Dylan Edwards to a season-ending shoulder problem, while Josh Mansour, Waqa Blake, and Moses Leota are also in the casualty ward.
However despite their inability to stay healthy, the Panthers sit in second spot.
"I wouldn't say surprised, I'm pleased. You find out a lot about your club and your team when you're faced with a few challenges, and we've met those challenges," Griffin said.
"We've shown a good resilience as a group. We've had five debutants this year and every time we've given someone an opportunity, they've taken it.
"We've still got a real battle on our hands going forward but at the moment, we've been going okay."