Domantas Sabonis produced 23 points, 10 rebounds and five assists to carry Indiana past Philadelphia 115-97 with Ben Simmon's 76ers crashing to a third straight NBA loss.
TJ Warren added 21 points, Myles Turner 14 and Jeremy Lamb 13 for the Pacers, who improved to 15-3 at home and snapped a two-game losing streak.
Doug McDermott also had 12 points for Indiana, while former 76er TJ McConnell added 11 points and 10 assists.
Simmons collected 18 points and 10 rebounds but also had three assists against six turnovers.
Josh Richardson led Philadelphia with 20 points but the Sixers (23-13) looked out of sync without All-Star centre Joel Embiid, who was nursing a sore left knee, and are 3-4 without him this season.
Since beating Milwaukee on Christmas Eve, they've dropped straight road games in Orlando, Miami and now Indianapolis.
With Embiid absent the Pacers bolted to a commanding 67-43 halftime advantage.
Simmons paced the Sixers with 12 points and seven rebounds but they continued to struggle mightily with their shooting and weren't able to cut much into the lead.
In Texas, DeMar DeRozan had 24 points and Patty Mills 18 as San Antonio escaped with a 117-113 overtime victory over Golden State.
Dejounte Murray scored seven of his 15 points in overtime with the Spurs getting their eighth win in 13 games. LaMarcus Aldridge added 17 points and 12 rebounds.
Alec Burks had 28 points and Glenn Robinson added 25 for Golden State.
James Harden and Russell Westbrook combined for 63 points as Houston put paid to Denver at home 130-104.
Harden paired 35 points with six assists while Westbrook added 28 points and seven assists to carry the Rockets to a seventh consecutive home win over the Nuggets.
Houston displayed exceptional first half ball movement but after the Nuggets sliced a 17-point halftime deficit to 92-89, they had to unleash a 19-3 surge to reclaim control.
In Charlotte, Jayson Tatum scored 24 points, Kemba Walker 22 and Gordon Hayward 21 as Boston beat the Hornets 109-92.
The Celtics have won six of seven and improve to 23-8.
PJ Washington led Charlotte with 15 points and Miles Bridges had 14 points and 10 rebounds. The Hornets have lost six straight.
Paul George had 21 points with season highs of 11 rebounds and nine assists in Sacramento as the short-handed Los Angeles Clippers prevailed 105-87.
Kawhi Leonard scored 14 of his 24 points in the third quarter while Ivica Zubac added eight and 13 rebounds.
Kyle Lowry scored 24 points and added eight assists as hosts Toronto defeated Cleveland 117-97.
It was the second win in 15 days for the Raptors over the Cavaliers, who have lost five straight in Toronto.
Chris Paul scored 17 points to lead the Oklahoma City Thunder to a come-from-behind 106-101 home win over the Dallas Mavericks to round out Tuesday's schedule.