NSW and Queensland will usher in the biggest changing of the guard in State of Origin history when teams are announced for next week's series opener on Monday.
Blues coach Brad Fittler will call in a record 11 debutants for the June 6 clash, as NSW desperately try to turn a new page after 12 years of Origin torment.
Meanwhile Queensland's list of rookies will be significantly shorter, but changes will come in the crucial positions of halfback and hooker.
Exactly 101 games of Origin experience have vacated the Maroons following the retirements of Cameron Smith, Cooper Cronk and Johnathan Thurston, with St George Illawarra's Ben Hunt expected to be the biggest winner.
Hunt will likely earn his first Origin starting spot when he is expected to be unveiled as Queensland's new No.7 on Monday, while Andrew McCullough will be the new dummy-half.
The changing of the guard will be accentuated even further if coach Kevin Walters opts against selecting veterans Matt Scott and Darius Boyd, who have played a further 49 games between them.
Scott will have to overcome a shoulder charge suspension to play in the match, but there was some suggestion on Sunday night he wouldn't be selected anyway following a poor start to the season with North Queensland.
Boyd is also battling to hang onto his spot from fellow incumbent winger Valentine Holmes, who will give the Maroons the closest thing possible to a first-choice goal-kicker.
Greg Inglis is expected to be named captain, making him the 12th person to lead Queensland in Origin following the retirement of Smith.
Meanwhile Blues captain James Maloney will be just one of six to survive the axe for NSW.
James Tedesco and James Maloney will be the only old faces in a new-look backline, that will include Nathan Cleary at halfback, Tom Trbojevic and Josh Addo-Carr on the wings and James Roberts and Latrell Mitchell in the centres.
David Klemmer and Jake Trbojevic (bench) are the others likely to survive from the forwards, which will include three Dragons in Tyson Frizell, Jack de Belin and Paul Vaughan (bench).
According to a final 17 leaked to News Corp Australia on Sunday night, South Sydney's Angus Crichton has won out in the battle for the final bench spot ahead of Tariq Sims while Damien Cook will start at hooker.
Tyrone Peachey will also be a bench interchange, after he was preferred ahead of Dragons hooker Cameron McInnes.