Holders Bayern Munich started with reserve goalkeeper Alexander Nuebel for their Champions League last-16 second leg against Lazio on Wednesday, with club captain Manuel Neuer sidelined by a cold.
Nuebel was given only his third start this season, with Bayern holding a 4-1 lead from the first leg.
The club world champions, who are bidding to reach the quarter-finals for the ninth time in 10 years, were also missing winger Kingsley Coman, who failed to recover from a leg injury.
Lazio coach Simone Inzaghi pulled a surprise with top-scorer Ciro Immobile rested and Vedat Muriqi starting up front alongside Joaquin Correa.
In midfield, Argentine Gonzalo Escalante started ahead of Brazilian Lucas Leiva while Adam Mursuic was deployed in a back three.
Algeria international Mohamed Fares and Italy's Manuel Lazzari started as the wing-backs.
Bayern Munich (4-2-3-1)
Alexander Nuebel; Benjamin Pavard, Jerome Boateng, David Alaba, Lucas Hernandez; Leon Goretzka, Joshua Kimmich; Leroy Sane, Thomas Mueller (capt), Serge Gnabry; Robert Lewandowski
Coach: Hansi Flick (GER)
Pepe Reina; Adam Marusic, Francesco Acerbi, Stefan Radu; Manuel Lazzari, Sergej Milinkovic-Savic (capt), Gonzalo Escalante, Luis Alberto, Mohamed Fares; Joaquin Correa, Vedat Muriqi
Coach: Simone Inzaghi (ITA)
Referee: Istvan Kovacs (ROU)