World champion Casey Stoner will be eager to end Jorge Lorenzo's recent dominance of the Spanish MotoGP on Sunday.
Spaniard Lorenzo, winner of the season-opening race in Qatar on April 8, has secured back-to-back victories at Jerez.
Another win at the circuit for the Yamaha rider would give him a handy advantage over Stoner in the riders' standings.
Stoner, who finished third, had superior pace on his Honda in the opening race before tightness in his right arm saw him slow down and allow Lorenzo past him to win.
The Australian would have worked on the physical issue in the fortnight since, but needs to right what has been a poor record in Spain.
Only once in six MotoGP races at Jerez has Stoner finished on the podium, while he was forced to retire last year after a collision with Valentino Rossi.
Rossi's troubles with his Ducati have continued into this year after he finished 2011 winless - the first time he has failed to claim victory in a season since starting in MotoGP.
The Italian seven-time world champion has been unable to make an impact at Ducati and said there needed to be change after his 10th place finish in Qatar.
"I can't ride this bike, I can't make the difference, I can't even keep up with (team-mate Nicky) Hayden's pace, who I used to go quick against in comparison," he told Mediaset.
"In theory, with new tyres I should go quicker. Nicky managed to do a good race with the other works Ducati, but he still ended up only sixth."
Stoner's team-mate Dani Pedrosa finished second in Qatar, while Cal Crutchlow ended up an impressive fourth on his Monster Yamaha.
The circuit at Jerez is among the most popular on the calendar, with its 13 corners providing riders with a stern test.
Lorenzo holds the lap record at Jerez, and the 2010 world champion will again be tough to beat as he aims for a hat-trick of wins in front of his home fans.