Carlton will welcome back Chris Judd, Jarrad Waite and Ed Curnow for Monday night's clash against St Kilda, but Chris Yarran remains just a '50-50' chance.
The Blues were without the quartet for Sunday's 67-point win over Greater Western Sydney, with all given a break due to minor injury concerns.
Coach Brett Ratten said on Wednesday while he was unsure whether Yarran would return against the Saints, Judd, Waite and Curnow were definite starters.
"Yarran's still 50-50, we'll have to wait more for Friday to see how he trains. He hasn't trained yet. The other three will definitely be back. We'll just wait on Yarran," Ratten said.
Ratten said the break had been crucial for two-time Brownlow Medallist Judd, who missed with general soreness, and added he would give the captain another rest if he needed it later in the season.
"The week's done him the world of good. He's been through a lot of pre-seasons," Ratten said.
"I suppose the way he plays the game and the way the opposition attack him. They put a fair bit of time and effort into him.
"If you looked at the physicality ratings that he has to endure through games, it would be fairly high. To overcome that soreness is really good for him."
Robert Warnock will miss up to a fortnight with a hamstring injury, with Matthew Kreuzer playing against the Giants after initially being ruled out with a knee complaint.
Ratten said managing Kreuzer's workload was a priority.
"It was more just about managing that knee. That's something that we're making sure we don't overload that knee. He's doing more work and game time is a lot higher," Ratten said.
"If we have the opportunity for any of those players to give them a spell, now that's probably made it harder with Robbie not being available for some time - whether it's a week or two. It just changes.
"He'll probably need another game back at reserves level so that will just change our view on when do we give Matthew an easier week, or an easier game, in regards to smashing in and the physicality on that knee. We need to look after him."
St Kilda sit ninth on the ladder with three wins from six matches, and took it up to Hawthorn at the MCG on Saturday night before going down by 35 points.
Ratten said he expected scoring against St Kilda - who have conceded an average of just 76 points per game this season - to be difficult.
"They're going well. Their stats indicate they're not conceding a lot of inside 50s, their scores against are really low," he said.
"They're really stifling the opposition in regards to that and their scoring has been pretty productive as well."