Cleveland trailed throughout the first half on the second installment of a five-game road swing. But after a sluggish start on Sunday, the Cavaliers settled in and took control in the second half.
LA held an 80-77 lead with less than four minutes to go in the third quarter. Cedi Osman knocked down a game-tying three-pointer at the 3:28 mark, and Cleveland never trailed again.
The Cavs (8-1) scored the final 10 points of the period, then the first seven to open the fourth for a decisive 17-0 run. Mitchell's and-one play to open the final term pushed the lead to 10 points, and it never dipped to single digits again.
LeBron James tallied a team-high 27 points for Los Angeles (2-7). Anthony Davis added 19 points and grabbed a game-high 12 rebounds, while Russell Westbrook came off the bench to chip in 19 points and dish 10 assists.
Cleveland's Kevin Love (10 points, 10 rebounds) was responsible for the fourth different double-double of the day.
After the Wizards, without leading scorer Bradley Beal who was in the league's health and safety protocols, rallied in the third quarter, the teams exchanged leads early in the fourth. Memphis went on a 9-0 run, with Morant scoring six, and the Grizzlies (7-3) held on for their third straight win.
In Toronto, Fred VanVleet returned from a back injury with season highs of 30 points and 11 assists, Scottie Barnes had 19 points and 10 rebounds, and the Raptors overcame the absence of leading scorer Pascal Siakam to beat Chicago 113-104.
O.G. Anunoby scored 22 points and Christian Koloko added a career-high 11 for the hosts.