Ten-time Coupe de France winners Marseille have crashed out in the quarter-finals of this year's competition after losing on penalties to second-tier FC Annecy.

Marseille's Leonardo Balerdi missed the decisive spot-kick for the hosts as Annecy joined Lyon, Nantes and Toulouse in the last-four courtesy of a 7-6 shootout win.

Jordan Veretout had given Marseille - second in Ligue Un - the lead after 29 minutes, calmly placing the ball into the corner after being put through by Jonathan Clauss.

Annecy turned the match around at the beginning of the second half when Dion Sahi equalised before Kevin Mouanga sent the visitors ahead.

The loud cheers at the Stade Velodrome changed to boos from the home fans venting frustration as the clocked ticked towards 90 minutes.

They reached a crescendo when Alexis Sanchez failed to convert a penalty after an 84th-minute handball.

Six minutes into stoppage time, however, Francois-Regis Mughe did get an equaliser to send the match to a shoot-out.

Toulouse and holders Nantes had reached the semi-finals earlier on Wednesday.

Nantes claimed a 2-1 win over Lens thanks to two penalties from Andy Delort while Toulouse crushed Ligue 2 club Rodez AF 6-1 at home.