The Team of Choice are placed sixth place on the log table with 28 points from 20 league matches, while Usuthu are placed eighth on the table having accumulated 26 points from 20 games.
Maritzburg suffered a 2-1 defeat to Orlando Pirates in their last league game which was played at the Orlando Stadium.
AmaZulu are placed eighth on the league standings with 26 points from 20 games. They are two points behind sixth-placed Maritzburg.
Usuthu are undefeated in their last five league games having recorded three wins and two draws.
Siyethemba Mnguni, who scored twice for AmaZulu when they beat their KwaZulu-Natal rivals Lamontville Golden Arrows at home in a league match two weeks ago, will be looking to continue his form against The Team of Choice and help Usuthu secure three points.
The Team of Choice are coming off a win over ABC Motsepe side Swallows in the Nedbank Cup Last 32 match which was played at the Dobsonville Stadium last weekend.
A brace from Andrea Fileccia helped Maritzburg beat Swallows 3-1 after extra-time and they will now be part of the Last 16 draw on Thursday.
On the other hand, AmaZulu drew 2-2 with Mthatha Bucks after extra-time in the Nedbank Cup Last 32 match which was played at the King Zwelithini Stadium last weekend.
Usuthu went on to secure their place in the Last 16 after defeating the National First Division (NFD) side 3-0 on penalties.
The last league meeting between Maritzburg and AmaZulu ended in a 1-1 draw at the King Zwelithini Stadium on the 12th of September 2017.
The winner between AmaZulu and Maritzburg will cement their place in the top eight on the league standings.