Aside from that, manager Rob Edwards has a fully-fit squad to choose from.
This is the first meeting between these sides since March 1994 when Luton won a FA Cup quarter-final replay 3-2 at Kenilworth Road.
The Hammers have gone four matches without a win against Luton since beating them in January 1992, in what was the Hatters' last season in the top-flight.
Kenilworth Road becomes the 61st different stadium to host a Premier League game.
This is Luton's first top-flight home fixture since a 2-0 win against Aston Villa on 25 April 1992.
In that 1991-92 season, they lost only four of their 21 home league matches, but were winless in all 21 league away fixtures.
The Hatters have lost both of their opening two matches of a league campaign for the first time since 2002-03 in the third tier.
They are aiming to avoid becoming only the second team to lose their first three matches of a top-flight season by a margin of three or more goals after West Brom in 1890-91.
Promoted teams have lost all seven of the Premier League games this season by an aggregate score of 18-4.
West Ham United
This is only the second time this century after the 2021-22 campaign that West Ham have remained unbeaten in all of their opening three matches to a league season.
David Moyes' side are aiming to win three consecutive league matches for the first time since January 2022.
A victory would see them top the table (having played at least four top-flight games) for the first time since October 1983.
They lost their first league match against promoted opposition last season, but won all five of their remaining such fixtures by an aggregate score of 14-1.
After failing to score an away goal in the Premier League last season, Jarrod Bowen could become the first Hammers player to score in their first three top-flight away games in a season since the club's all-time top scorer Vic Watson in 1930-31.