Bayern Munich's world player of the year Robert Lewandowski has been ruled out of the Bundesliga title crunch match at RB Leipzig with a knee injury which could also end his hopes of a record goalscoring season.
The 32-year-old striker strained a ligament in his right knee after scoring twice in Poland's 3-0 win over Andorra on Sunday, and has returned to Munich for assessment by Bayern's medical team.
Bayern said on Tuesday that Lewandowski would be out "for around four weeks," a recovery time-frame which would also see him miss the Champions League quarter-finals with Paris St Germain.
Lewandowski has scored 35 Bundesliga goals this season and was closing in on Gerd Muller's record of 40, set in 1971-72 and once thought unbreakable.
Should he return as expected, the Pole would only have three more Bundesliga games available to match or better Muller's tally.
Bayern top the table four points ahead of second-placed Leipzig and with a victory would take a big step towards a ninth straight title.
But in addition to Lewandowski being absent, defenders Alphonso Davies and Jerome Boateng are suspended.
Eric Maxim Choupo-Moting could come in as a direct replacement for Lewandowski up front or Thomas Muller could be used as a striker should coach Hansi Flick elect to shuffle his pack.
Leipzig, meanwhile, are taking nothing for granted as they look to keep alive their hopes of a maiden title.
"Bayern will field a competitive team even without Lewandowski," sports director Markus Krosche told Tuesday's Bild paper before the extent of his injury was known.
"You don't want this to happen to anyone but we are concentrating on ourselves."
Lewandowski was initially thought likely to miss Saturday's game but his time was expected to be five to 10 days rather than almost a month.