Australian Minjee Lee is contention to win the LPGA Tour's first event back from its coronavirus enforced shutdown in February.
Lee carded a one-over 73 on Saturday to be two-under par and in a share of sixth at the Drive On Championship - just three strokes off the lead.
France's Celine Boutier (71) and Britain's Jodi Ewart Shadoff (72) birdied their final holes of round two to grab a share of the lead alongside American Danielle Kang (73) heading into the final day.
The scene is set for an enthralling conclusion in Toledo, Ohio, with Sarah Schmelzel (69) and Japan's Yui Kuwamoto (71) tied for thirdat three-under.
Kang, who won the Women's PGA Championship in 2017, began a rainy day at the famed Inverness Club alone atop the leaderboard, one shot clear of Ewart Shadoff.
But world No.4 Kang suffered a late-round wobble, taking three consecutive bogeys from the 13th hole.
"Today was a complete different challenge than yesterday," American Kang, who carded a 66 in the opening round], said.
"It was a different game. It was different golf course.
"All of a sudden it's gotten cold, it was raining, everything is wet."
Ewart Shadoff, who has more than 20 top-10 finishes, has never won an LPGA event.
Boutier turned in a scrappy effort mixing three bogeys with four birdies but was just one of nine players to post an under-par round.
"I feel like I can handle tough weather conditions pretty well," she said.
"So I feel like whenever the conditions are tough, I kind of actually like it... It's a good challenge and I think especially on this course you have to be very, very smart."
The restart event is missing some of the biggest names in women's golf with top-ranked Ko Jin-young and Park Sung-hyun among a number of top international players who decided to sit out because of COVID-19 concerns.
The only other Australian to make the cut after round, Sarah Kemp, is tied for 43rd at four-over after a 75 on Saturday.