NSW could blood another two debutants after coach Brad Fittler revealed Luke Keary was drafted into the Origin II squad as cover for a hobbling James Maloney.
Fittler on Saturday night announced a 20-man squad for the ANZ Stadium match, with injured prop Reagan Campbell-Gillard the only player missing from the one that beat Queensland in the series-opener.
Fittler has a number of options to replace Campbell-Gillard, including handing Gold Coast captain Ryan James, Cronulla's Matt Prior, or game one 18th man Tariq Sims their Origin debut.
However, Keary could also be rushed in after should Maloney fail to recover from a pinched nerve in his back that he injured in Penrith's loss to the Sydney Roosters on Friday.
"If you saw him at the end of the game, he was struggling. He had a dropout where he couldn't complete the kick really," Fittler said on The Sunday Footy Show on the Nine Network.
"The last couple of minutes he was holding his back, a little sciatic nerve.
"Speaking to some people about those sort of injuries, they can be quite painful and hang around while other people say they can come and go, the flare-ups might just go."
Prior has seemingly overtaken the likes of former NSW forwards Aaron Woods, Trent Merrin, Josh Jackson and Wade Graham in the pecking order.
Fittler described Prior as a like-for-like replacement for Campbell-Gillard, and suggested that he could be swayed by the Maroons' forward selections.
"They're two different style of footballers. Ryan's renowned for playing big minutes while Matt's quite explosive, he's a bit more like Reagan Campbell-Gillard," Fittler said.
"At times you need size just to be able to absorb some of those blokes like Josh Papalii and Matt Scott, if he plays. But once all that sting goes out of the game, the size doesn't matter as much."
Sharks coach Shane Flanagan insisted Prior wouldn't let anyone down if selected.
"I spoke to Freddie (on Friday night). He didn't say he was in, he just said he was looking at him and asked a few questions about him," Flanagan told AAP.
"It's a good reward for him. 2016 he was fantastic, same as 2017, and he's found his form again this year. It's a great reward for a bloke who's worked really hard for a long period of time."
The Blues begin gathering in camp Coogee on Sunday.
NSW 20-man squad for game two: Josh Addo-Carr, Nathan Cleary, Damien Cook, Boyd Cordner (capt), Angus Crichton, Jack de Belin, Tyson Frizell, Ryan James, Luke Keary, David Klemmer, James Maloney, Latrell Mitchell, Tyrone Peachey, Matt Prior, James Roberts, Tariq Sims, James Tedesco, Jake Trbojevic, Tom Trbojevic, Paul Vaughan.