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Roger Federer will miss the Australian Open in January and is unlikely to return to competitiion until mid-2022 as he recovers from multiple knee surgeries.
This is the second year running the former world No.1 will miss the opening grand slam of the year.
Federer, 40, also said he would be "extremely surprised" if he was able to play at Wimbledon, a tournament he has won a record eight times with his last title coming in 2017.
The 20-times grand slam champion said he would be able to resume running in January and return to training on the court in March or April.
"I need to be very patient and give my knee the time to heal. The next few months will be crucial," Federer said in an interview carried by several Swiss media outlets.
Federer's agent did not immediately respond to a request for comment.
Federer is tied on 20 grand slam titles with Rafa Nadal and Novak Djokovic in the race to become the most successful men's singles champion of all time.
His coach Ivan Ljubicic had said earlier this week Federer was unlikely to play at Melbourne Park in January as he was not going to be 100 per cent fit.
Federer had two knee operations in 2020 that kept him out of the tour for more than a year and returned to action in March, but he played only 13 matches this year.
He withdrew from the French Open in June after winning his third-round match to save himself for Wimbledon but fell at the quarter-finals hurdle at the grass court grand slam a month shy of his 40th birthday.
Another injury forced Federer to skip the US Open as he went under the knife again and he said doctors also fixed cartilage in his knee.
"This summer it was decided to suture the lesion to my meniscus, which involves some downtime," he said. "The doctors took the opportunity to also treat my cartilage. The combination of these two procedures requires patience and caution."
Federer has not won a grand slam since clinching the Australian Open title in 2018 but the Swiss veteran said he is still holding out for a 'miracle'.
"My life is not going to collapse if I don't play a grand slam final again," he added.
"But it would be the ultimate dream to go back. And in fact, I still believe in it. I believe in these kinds of miracles."