The England all-rounder struck 59 runs from 38 deliveries at Lord’s on Sunday to lead Anya Shrubsole’s team to a 34-run win.
That final knock also saw Wyatt replace England team-mate Tammy Beaumont as the top run-scorer in the women’s competition for 2023 with 295.
Freya Kemp's 31 and Georgia Adams' 27 lent support as the Brave piled up 139 for six on a dry pitch, despite three for 21 for England seamer Kate Cross.
Jemimah Rodrigues, starved of strike for long periods, made 24 in the chase, but Kalea Moore returned three for 15 and Lauren Bell three for 21, while there were a trio of stumpings for Rhianna Southby as Superchargers were bowled out for 105.
It meant the Brave, bridesmaids in the first two finals, finally got their hands on the trophy, a fitting end to a glittering career for retiring skipper Shrubsole, who took the match-clinching wicket in England's World Cup winning triumph against India at the home of cricket six years ago.
Much of the Brave's success on the run to the final had been built on the triumvirate of Smriti Mandhana, Wyatt and Maia Bouchier, but after being put in, two were gone in the blink of an eye.
Mandhana dismissed the first ball of the match to the point boundary only to slice the next from Grace Ballinger to fly-slip, while Bouchier played too soon at one from Cross to leave the Brave eight for two.
However, Wyatt produced a gem of an innings as the England batter played shots all around the wicket, sweeping effectively and hitting inside out over the off-side in racing to 50 from 35 balls with nine fours. A glorious straight six followed as she and Adams added 84 in 63 balls.
A mix-up meant Cross' underarm throw ended Wyatt's knock prematurely and Adams, dropped earlier by Georgia Wareham, holed out to the same fielder for 27.
An extraordinary cameo from Kemp, including swinging the bat out of her hands, lifted the Brave above par before she and Chloe Tryon both fell in Cross' excellent final set.
Marie Kelly was given out lbw to the first ball of the chase from Bell, only to be reprieved on review, but undeterred the England speedster bowled her off the pads with the second.
Phoebe Litchfield took up the chase with two dismissive early fours in a bid to overhaul Wyatt once more as leading runscorer.
She would though only get to 13 before swinging another Bell delivery to a catcher in the deep.
Rodrigues picked up five from a misdirected Tryon throw at the stumps, but only 28 came from the powerplay.
Wicketkeeper Southby then took centre-stage with two brilliant pieces of glovework to stump first Hollie Armitage and then England newbie Bess Heath, the latter having previously hit Bell over the ropes for six.
Shrubsole joined in the fun with a farewell wicket of Alice Davidson-Richards and once Rodrigues holed out in the increasingly desperate pursuit of boundaries, Brave were all but home.
Additional reporting by the Press Association.