GWS will be without veteran defender Phil Davis in their AFL clash with Hawthorn, while hamstrung teammate Zac Williams could also be set for another stint on the sidelines.
Davis and Williams both suffered hamstring injuries in the third quarter of the Giants' gutsy two-point win over Collingwood on Friday night.
The former co-captain and rebounding defender are both in doubt for the Giants' round-five match against the Hawks, although coach Leon Cameron was more upbeat about Williams than Davis.
"We wait and see. Hopefully it's only a couple of weeks (that Davis misses)," Cameron told reporters.
"He was terrific up until he hurt his hammy, he really led the back line.
"It's not a big one.
"Zac is more tight at the moment, so we're fingers crossed ... we didn't want to take a risk."
Williams returned from an achilles injury in round two against North Melbourne, while he was also one of the Giants' most influential players against Collingwood before his setback.
"Hopefully we can get him up and ready for next week but we'll find out in the next 48 hours," Cameron said.
Cameron was full of praise for the way his side, reeling from upset losses to the Kangaroos and Western Bulldogs, found form and dug deep despite being down on rotations.
"To find a way with a couple down in the last quarter was really pleasing," he said.
"Everyone's going to ebb and flow in this competition. We see sides win a couple in a row or lose a couple in a row.
"We still need to get to work on some areas."