It has become the biggest R-rated comedy worldwide since Bridget Jones's Baby, met with positive reviews and reigniting viewer's love with Natasha Bedingfield's smash hit 'Unwritten', which features in the film.
So it seems fitting then that Powell celebrated Anyone But You by posting a naked picture to his Instagram page.
In the final picture of his carousel post, he is seen covering his modesty with a piece of white card featuring the lyrics to Bedingfield's single, which has now re-entered the UK Top 20 Singles Chart.
Powell penned an emotional caption to the post, which gave fans a behind-the-scenes glimpse at Anyone But You, thanking the film's viewers for the "surreal" response.
"It’s hard to put into words the journey of Anyone But You," he began. "The response to this movie has been surreal. Not only have audiences have shown up, but this film has grown week after week, something very few movies have ever done.
We just crossed $100 million at the box office because of the fans. You laughed loud, you cheered loud, and you danced out of the theaters all over the world. Your joy was powerful and infectious."
He went on to extend a special message to Sweeney, writing: "And special thank you to our Queen Bea. The beautiful force that is @sydney_sweeney who allowed me to come on this ride with her and for leading our cast with kindness and vision every step of the way.
"Thank yall for spreading the love and reviving the RomCom."
Sweeney shared the love, commenting: "Thank you for going on this wild fun ride with me :) forever my favorite 🐝📖."
The film also stars Alexandra Shipp, Michelle Hurd, Rachel Griffiths, Bryan Brown and Dermot Mulroney, with director Will Gluck penning the script alongside Ilana Wolpert.
Anyone But You is available in cinemas now.
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