The Greek superstar bagged 42 points on 20-of-23 shooting in Monday night's match in Washington.
Antetokounmpo shot 87.0 per cent from the field, the highest mark in a game by a player with at least 20 attempts since Mike Woodson of the Kansas City Kings went 22 of 24 (91.7 per cent) in a 48-point effort against Houston on February 20, 1983.
Washington dropped a sixth straight, but not without putting up a decent fight against the star-studded Bucks. Jordan Poole scored 30 points for Washington, and Kyle Kuzma added 22 points and 13 assists.
In Detroit, Reggie Jackson scored 21 points and carried defending champions Denver in the fourth quarter after two-time MVP Nikola Jokic was ejected as the Nuggets handed Detroit their 12th straight loss - 107-103.
Jokic and Denver coach Michael Malone were ejected after arguing calls. Malone was thrown out for coming onto the court to dispute a call late in the first quarter, and Jokic was tossed for picking up a second technical with 1:22 left in the second period.
In Charlotte, Miles Bridges hit a 3-pointer with 6.6 seconds left in overtime as he Hornets beat Boston to snap a six-game home losing streak in a 121-118 win.
Wembanyama, the No.1 pick in the draft, was held to nine points and three rebounds.
In Chicago, Bam Adebayo had 23 points and 11 rebounds as Miami topped Chicago 118-100, two nights after blowing a 21-point lead in the same building.
Jimmy Butler scored 16 points against his former team, while Adebayo earned his eighth double-double of the season.
Minnesota (10-3) are 6-0 at home - tying a franchise record to start a season - and have won nine of their past 10 games.
In New Orleans, Brandon Ingram hit all five of his 3-pointers and led all scorers with 31 points, and Zion Williamson dominated the paint by scoring 26 points on 12-for-16 shooting to power New Orleans to a 129-93 win over Sacramento.