Knoops last touchdown pass, a 25-yarder to Jimmy Kibble, capped a five-play, 69-yard drive with 1:45 left to force overtime after the Bison had scored 29 unanswered points.
After that fast finish, Bucknell was held to one yard in OT and settled for Matt Schearer's 41-yard field goal.
Knoop connected with Kibble for a 95-yard touchdown at 4:41 of the third quarter for a 37-15 lead.
Ralph Rucker then ran for a two-point conversion after Rushawn Baker's 38-yard TD and threw three touchdown passes covering 65, 32 and 28 yards. The 32-yarder to Eric Weatherly tied the game at 37.
The Bison scored on 4 of 5 possessions but had to punt from midfield in the final minute.
Knoop was 27-of-38 passing for 361 yards but had two interceptions. Kibble had 179 yards on eight catches. The Hoyas (5-5, 3-2 Patriot League) had 422 yards of offense.
Rucker was 20 of 41 for 296 passing and threw two interceptions. Baker finished with 97 yards rushing and three touchdowns. Bucknell (3-7, 1-5) had 432 yards.
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