Coronavirus-hit Fremantle will unveil their generation-next forward line in Friday night's AFL clash with North Melbourne at Optus Stadium.
Teenagers Josh Treacy and Jye Amiss will be relied on to fill the key forward spots after Rory Lobb (COVID-19 protocols) and Matt Taberner (hamstring) were ruled out of the match.
Taberner, who missed last week's win over Geelong, is set to be sidelined for another two to four games.
Lobb could miss next week's clash with Gold Coast depending on his fitness level after his stint in isolation.
Treacy booted 13 goals in 15 games in a solid debut season last year but he has managed just one major in two matches in 2022.
The 19-year-old will play an important role against the Kangaroos given he will also be offering ruck support for the returning Sean Darcy (concussion).
"We're confident that Josh Treacy has done enough ruck work at Peel and he can step up," Fremantle coach Justin Longmuir said.
"We're going to have to manage a few things around the centre bounce but he's done that role in preparation for this opportunity."
Amiss will be making his AFL debut after booting eight goals in his past two WAFL outings.
The 18-year-old was snared with pick No.8 in last year's national draft, becoming the first key forward to be picked inside the top 10 by Fremantle since Matthew Pavlich in 1999.
Amiss has had a slow build-up this year after arriving at the Dockers with a pre-existing knee injury and then experiencing some quad soreness during the pre-season.
But his stunning performances over his past two WAFL matches convinced Fremantle he is ready to go.
"He's been playing full game time at Peel and he's been unrestricted in terms of game time at Peel for at least the last month," Longmuir said.
"So that aspect is fine, and he's ready to play and contribute at AFL footy, there's no worries there."
The third-placed Dockers (6-1) have six players ruled out of the Kangaroos match due to COVID-19 protocols - Lobb, Lloyd Meek, Griffin Logue, Blake Acres, Travis Colyer and Michael Frederick.
But such is Fremantle's depth that Longmuir is confident it won't affect their performance too much.
Defenders Heath Chapman and Hayden Young return from their own stint in isolation while Darcy, Bailey Banfield, Liam Henry and Amiss are the other confirmed inclusions.
North Melbourne (1-6) will be without their leading goalkicker Nick Larkey as he serves a one-game ban for tunnelling Carlton's Lewis Young.
The Kangaroos axed Jack.Mahony, while Aiden Bonar and Miller Bergman were ruled out through injury.
Jed Anderson has been called up for his first game of the season after making a successful return in the VFL, while Aidan Corr and Ben McKay also earned call-ups.