It is a particularly early stage for Spurs to enter the competition, having failed to qualify for European competition last season, and manager Ange Postecoglou has been dealt a difficult hand.
Going away to Craven Cottage is not an easy start as the Australian looks to deliver a trophy during his first season in charge.
Here’s everything you need to know.
Date, kick-off time and venue
Fulham vs Tottenham is scheduled for a 7.45pm BST kick-off time tonight, Tuesday, August 29, 2023.
Craven Cottage will host.
Where to watch Fulham vs Tottenham
TV channel and live stream: The game will not be broadcast in the UK.
LIVE coverage: Follow all the action with Standard Sport’s dedicated match blog.
Fulham vs Tottenham team news
For Spurs, Postecoglou is confident Destiny Udogie is not injured and was only taken off against Bournemouth as a precaution. The manager has confirmed he will make changes after making minimal so far in the Premier League.
Fulham vs Tottenham prediction
A difficult task for Spurs but given their form - and Fulham’s struggles - they should have enough about them to secure a narrow win.
Spurs to win 2-1.
Head to head (h2h) history and results
Fulham wins: 18
Tottenham wins: 54
Fulham vs Tottenham latest odds
Fulham to win: 5/2
Tottenham to win: 19/20
Odds via Betfair and subject to change.