Erik ten Hag’s side beat Newcastle in last season’s final, as goals from Marcus Rashford and Casemiro ended the club’s six-year wait for a trophy in the Dutchman’s first campaign at Old Trafford. United have still lost three of their six Premier League matches so far this season though. Mason Mount and Harry Maguire are among those who start for the hosts, while Sofyan Amrabat is handed a full debut.
Man Utd vs Crystal Palace live: Latest score and updates from the League Cup third round
Reading’s cash crisis is under further scrutiny after the League One club were placed under a transfer embargo for failing to pay HMRC on time.