Yvette D'Ath has denied any ill will towards Queensland Premier Annastacia Palaszczuk following her removal from the troubled health portfolio in a cabinet reshuffle.

Ms D'Ath swapped roles with attorney-general Shannon Fentiman in a decision that saw the dials shift for eight ministers.

She said there were no feelings of betrayal towards Ms Palaszczuk and supported the move in the best interests of the Labor government.

"There's no issue at all. I am proud to work with the premier. I think she's an exceptional premier, has been, was in opposition, and has led this state admirably since coming into government in 2015," she told reporters on Thursday.

"I will support the premier with whatever decision she makes about who sits in cabinet and the roles they play."

Ms D'Ath had come under fire from opposition MPs in the past 12 months for surging ambulance ramping and debacles involving health services across the state.

She said the sheer size of the government's health portfolio made the role challenging, but was proud of what the department had achieved.

"I'm very proud of the work I've been able to do with health. I've relished the opportunity. A lot of people said it was the poison chalice when I went in and I said, not at all. I was thrilled with the opportunity to do it and I still am," Ms D'Ath said.

The premier cited Ms D'Ath's navigation of the pandemic as a significant achievement, but she wanted fresh eyes and energy in the health portfolio.

"Yvette was an incredible attorney-general in our state - very well regarded - and it is my view that she is better suited to that role," Ms Palaszczuk said.

"But the health portfolio is huge and we need to be more responsive.

The premier said Ms Fentiman was "the best person to be the health minister and it is my view that Yvette D'Ath is the best person to be state attorney-general".

The opposition criticised Ms D'Ath's tenure as health minister and previous stint as attorney-general, and said Ms Fentiman would not bring change.

"In the eight years and four health ministers of the Palaszczuk Labor government, Queensland's health crisis has deepened," LNP spokeswoman Ros Bates said in a statement.