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Fremantle's COVID-19 outbreak has grown to six players with Griffin Logue, ruckman Lloyd Meek and forward Michael Frederick the latest players to be ruled out.
Forward Rory Lobb, Blake Acres and Travis Colyer were forced into the health and safety protocols earlier this week and they have since been joined by Logue, Meek and Frederick.
Dockers coach Justin Longmuir is cautiously optimistic there will be no further players ruled out for Friday night's clash with North Melbourne at Optus Stadium.
Longmuir confirmed last year's No.8 draft pick Jye Amiss will debut after booting a combined eight goals in his past two WAFL games.
Ruckman Sean Darcy (concussion), Heath Chapman (protocols), Hayden Young (protocols) and Bailey Banfield (unused sub) will all return to the 22.
Fremantle have taken extra precautions in a bid to avoid COVID-19 this season, but Longmuir feels their trip to GMHBA Stadium last week -- to post a famous three-point win over Geelong -- was the likely source of the outbreak.
"After a good win you tend to get a bit more touchy-feely and closer and sing the song together," Longmuir said.
"Then we sat on a bus for an hour, sat on a plane for four hours and then sat on another bus back to the club for 40 minutes.
"It could have happened in that time."
Amiss is the first key forward Fremantle have selected inside the top 10 since Matthew Pavlich in 1999, and there are huge hopes for the 196cm 18-year-old.
"He's got some elite forward craft," Longmuir said.
"We're not going to see the finished product by any stretch.
"He's got a lot of work to do in the gym and fitness, and he's going to add layers and layers to his game.
"But he's a good mark and he's got high footy IQ.
"He can hit the scoreboard in different ways. He's an exciting prospect."
North Melbourne will be without their leading goalkicker Nick Larkey after he was given a one-game ban for tunnelling Carlton's Lewis Young.
Fremantle are flying high with a 6-1 record while the Kangaroos (1-6) face a fight to avoid a second consecutive wooden spoon.