Usman Khawaja has been dropped from Australia's Test side, while Steve O'Keefe is in for a three-pronged spin attack.
O'Keefe has replaced the injured Josh Hazlewood, who flew home after the first Test.
Hilton Cartwright has come in for Khawaja to provide pace depth.
It is the first time since the Bangladesh tour of 2006 that Australia have played three spinners.
But weather may yet cruel the tourists' hope of levelling the series, with rain forecast for all five days.
Australian XI: Warner, Renshaw, Smith, Handscomb, Maxwell, Cartwright, Wade, Agar, Cummins, O'Keefe, Lyon