Richmond have recalled fit-again premiership players Trent Cotchin, Dion Prestia, Josh Caddy and Shai Bolton for Sunday's clash with Adelaide.
The Tigers, who slipped out of the top eight after losing two of their past three games, have also included Callum Coleman-Jones and Mabior Chol in an enlarged squad for the game that is now being staged at Giants Stadium in Sydney.
The club says Bolton's broken wrist, sustained in a nightclub altercation, has healed.
Bolton has only missed two games, captain Cotchin has been hamstrung since inspiring a round-seven win over Western Bulldogs, and Dion Prestia (calf) has been on the sidelines since round three.
West Coast star Elliot Yeo and Essendon's Jake Stringer are back for their sides' clash at Optus Stadium on Saturday, with Hawthorn veteran Shaun Burgoyne also likely to return from injury this weekend.
Key forward Tom Lynch (knee) headlines Richmond's omissions, while the Crows are set to call up defender Will Hamill in place of dumped midfielder Ronin O'Connor.
St Kilda coach Brett Ratten, who vowed to swing the axe after an embarrassing 111-point loss to Western Bulldogs, made five changes for Saturday's match against North Melbourne at Marvel Stadium.
Debutant Oscar Clavarino, Nick Coffield, Luke Dunstan, Mason Wood and Tom Highmore are in the Saints' side at the expense of Hunter Clark (groin), James Frawley (shoulder), Shaun McKernan (toe), Jack Bytel and Jack Lonie.
Port Adelaide coach Ken Hinkley also made a selection statement, dropping vice-captain Hamish Hartlett while recalling Orazio Fantasia for Sunday's clash with Fremantle at Adelaide Oval.
The Dockers, who were forced to omit Matt Taberner (ankle), included young gun Andrew Brayshaw in their squad.
Yeo will play his first match since round 11 of 2020.
The Eagles also promoted Jamaine Jones, while dumping Harry Edwards and Jake Waterman.
The Hawks recalled Burgoyne, Liam Shiels and Josh Morris for Saturday's clash with Gold Coast that is now at the SCG, with Kyle Hartigan (suspension), Jaeger O'Meara (concussion) and Oliver Hanrahan making way.
"The playing group had to cut its training session short and leave abruptly ... there could be some changes," Hawks head of football Rob McCartney cautioned.
Collingwood's hopes of upsetting Geelong took a blow after Taylor Adams (knee) joined Tyler Brown (shoulder), Josh Thomas (ankle) and Beau McCreery (calf) in being an enforced omission for Saturday's MCG clash.
Midfielder Trent Bianco will become the Magpies' seventh debutant of the season, while the Cats have replaced Mitch Duncan (concussion) with first-year midfielder Max Holmes.
Brisbane have named an unchanged side for Saturday's meeting with GWS at the Gabba.
The Giants have promoted Xavier O'Halloran as they seek to fill the immense void left by injured key defender Sam Taylor (ankle).
Sydney have added ruckman Callum Sinclair and six other players to their squad for Sunday's SCG match against Carlton, with Tom Hickey (knee), Robbie Fox (eye) and Nick Blakey the confirmed omissions at this stage.
Key forward Levi Casboult is one of five inclusions in Carlton's squad.